Sabrina Cuddy • September 3, 2024
Septal Reduction September

If you have been experiencing symptoms of obstruction, such as shortness of breath, exercise intolerance, light-headedness, or fainting, despite using medications, it might be time to consider septal reduction. The most appropriate septal reduction therapy for each patient depends on several factors, which you can discuss with your HCM team. If you need assistance understanding these options or guidance on communicating with your doctor, we are here to help. Please do not hesitate to reach out to the  HCMA  for support. 

Camzyos  is the first FDA-approved medication for alleviating symptoms of obstruction in HCM. It’s worth a try for some individuals before considering invasive procedures. It may serve as a long-term solution for others, helping them avoid invasive procedures. However, since it’s relatively new, we are still learning about its full potential. Other medicines for this purpose are also currently in clinical trials, showing continuous progress in the field. 

A septal  myectomy  is an open-heart surgery that effectively treats the obstruction to blood flow caused by the thickening of the heart muscle or issues with the mitral valve, papillary muscles, or chordae. Patients who undergo myectomy often report rapid relief of their symptoms. For individuals with atrial fibrillation (AFIB), a  MAZE  procedure may be performed at the same time. Because open heart surgery allows all of these procedures to be performed at one time, and because of the relief of symptoms, the myectomy is called “the gold standard” of septal reduction. The safest place to have a myectomy is a high-volume  Center of Excellence  for HCM, ensuring the best care and outcomes. 

For those with the appropriate anatomy, an alternative procedure called  alcohol septal ablation  (ASA) is available for septal reduction. This less invasive method involves threading a thin, flexible catheter through a blood vessel in your groin to the artery that carries blood to your septum, where alcohol is inserted. Myectomy has a stronger track record of both safety and success than ASA. ASA might be recommended for individuals deemed at poor risk for surgery due to age or other medical conditions. However, it’s important to remember that ASA cannot be performed on every patient.

In conclusion, both Camzyos and septal reduction procedures offer hope and potential relief for individuals with HCM. The ongoing progress in treatments and options is truly inspiring, and we are committed to supporting you every step of the way. Please feel free to contact the HCMA for any assistance you may need.

HCMA Blog

April 30, 2025
Medical Management means using medicines and other non-invasive therapies to relieve symptoms. It's exciting that new treatments for HCM are being studied and that the FDA approved Camzyos in 2022! HCM can cause various symptoms depending on how stiff the heart is, how much scarring (fibrosis) there is, and whether there is obstruction. Some people have no noticeable symptoms. Common symptoms are chest pain/pressure, shortness of breath, lightheadedness, fatigue, palpitations, and brain fog. Syncope (fainting) is dramatic but not as common as the other symptoms. Medications are the first-line treatment for symptoms of HCM. If patients can't take one class of medication, they can try a medication from a different class. Here are some medications used to treat HCM and what they're for: Beta Blockers - make your heart beat slower and relax better. They allow the heart to fill more completely between beats. They can lower blood pressure and relieve symptoms. Calcium Channel Blockers - used to lower blood pressure and slow the heart rate. May reduce symptoms from obstruction in HCM. Myosin Inhibitors - cause the heart to beat with less force. They may reduce obstruction and septal thickness in some patients. Camzyos (mavacamten) is the first of this class of medication. For more information, click HERE . Antiarrhythmics - help to restore normal rhythm in the heart. Blood Thinners - anticoagulants and anti-platelets make it harder for blood to clot. They are prescribed to reduce the risk of stroke. This risk is higher in patients with afib, aflutter, and artificial heart valves. Diuretics , or "water pills," help the kidneys get rid of extra water and salt, reducing swelling in the body. Sodium Channel Blockers - may reduce gradient in obstructive HCM and can treat chest pain. Some also act as antiarrhythmics. Antibiotics - treat or prevent bacterial infections. In HCM, they may be given before dental work to prevent infective endocarditis. To learn more and see the side effects of these medications, click HERE .
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