Disopyramide and elevated PSA?

[BrooksK]

I'm on a beta blocker (nadolol) and disopyramide. My most recent blood tests indicate an elevated PSA. In Dr. Sherrid's presentation "Evaluation and Selection for Symptomatic LV Outflow Obstruction" given at the HCMA conference, he noted that disopyramide has "vagolytical side effects, dry mouth and exacerbation of prostatism."

I have a follow-up appointment with a urologist in a week, but are there any words of wisdom about the disopyramide/prostate connection?

Probably unrelated, but I also have continuing hypertension. When I started the beta blocker in January, I discontinued Benicar and amlodipine (which exacerbated the HCM SOB symptoms), but my pulse is really low (40 - 50), but BP in Stage I Hypertension. Various side effects with other BP meds (including cough and increased uric acid/gout). Again, any words of wisdom as to which drugs help with HBP, but don't exacerbate HCM symptoms? (Yes, I do have calls into my HCM doc, but my local doc seems determined to do whatever is needed to lower BP since there's the nice objective, measurable standard of what the numbers should be while the HCM symptoms are a bit more subjective . . .)

Does anyone ever take fewer drugs? Anyone note any difference with HCM with low Vit D levels? That, too, showed up on the blood test, so I'm also taking Vit D supplement now . . .

[Cynaburst]

Being female, I don't know much about how Disopyramide affects the prostate directly. I did know that when I took it, I was thirsty all the time (parched more like) and had problems peeing. It happened eventually, but it took awhile. I also did not sweat too much. I could go for long workouts and not ever break a sweat.

[Pam Alexson]

I can comment on the D deficiency but, they believe mine has been from gastric bypass. I have an option of 50,000 iu's of D a month or 1000 iu's a day and the latter is how I manage it. Are they also checking your ionized calcium levels? Is there a suspicion that something is wrong with your parathyroids? If you are low on D chronically then the calcium cannot adhere in the cell and you will be low in both calcium and D. I have found a direct correlation to low calcium from D depletion and how bad my chest pain can be. When I had my thyroid out ( in recent months) as my calcium levels fell the chest pain was most unbearable. As my thyroid levels fluctuate other areas of balance fall out of line as well.
Perhaps they should be checking on all via a good endocrinologist.

I also have gout even though it is more common in men then women and they believe that was prompted by high doses of diuretic and less hydration at times and high calcium intake aggravates it as well. I take allopurinol 100mg every night, long term and it helps to control this and ultimate stone formation.

For me we just keep adding pills, so I hear ya!