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Current Research Trials

Not all clincial Trials are listed here, but they can be accessed via this direct link to ClinicalTrials.gov  (directly linked to all HCM trials), which lists all trials and is updated daily. 
HCMA has short-listed those we feel you should be aware of on this page. The HCMA does not specifically endorse any trial on this list. We encourage each person to speak with their HCM care provider about which, if any, trial may be appropriate for them.  We encourage you to read
this link before participating in a clinical trial.  


Study Type Objective Link
Interventional Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy LIBERTY-HCM
Interventional A study in gene positive patients VANISH Study 
Observational Genetic Testing Genetic Predictors of Outcome in HCM Patients
Observational Prevalence of microvascular obstruction by MRI in participants who may or may not have had an acute heart attack Using Magnetic Resonance Imaging to Evaluate Heart Vessel Function After Angioplasty or Stent Placement Procedures
Observational  Identification of novel risk markers HCMR – Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
Interventional  If treatment with valsartan will have beneficial effect in early hypertrophic cardiomyopathy Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM
Observational Identify genes that cause cardiomyopathy or that influence how people with cardiomyopathy do over time.  Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
Observational  How helpful measuring cardiac biomarkers in Pediatric cardiomyopathy Cardiac Biomarkers in Pediatric Cardiomyopathy (PCM Biomarkers)
Interventional Develop a process to integrate WGS into clinical medicine and explore the impact of doing so. A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
Interventional Change in LVM after 3 months and 6 months of treatment using magnetic resonance imaging. Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy
Observational Investigation of sub-maximal exercise ventilation parameters in patient diagnosed with, or suspected to have, advanced heart failure. Prospective Observation of Exercise Parameters in Advanced Heart Failure
Observational  enhance and evaluate IT infrastructure developed to provide timely genetic variant updates and patient search functionality to clinicians to assist in optimizing patient care. Refining Information Technology Support for Genetics in Medicine
Interventional Test the potential beneficial efffect of over-the counter study anti-oxidant drug called N-acetylcysteine (NAC) in patients with HCM. Hypertrophic Regression With N-Acetylcysteine in HCM
Interventional Safety and potential benefits of moderate intensity exercise in patients with hypertrophic cardiomyopathy Study of Exercise Training in Hypertrophic Cardiomyopathy
Interventional If starting diltiazem administration early in life (in the prehypertrophic phase) will decrease the progression of HCM in individuals with sarcomere gene mutations Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem
Interventional Evaluate the safety and efficacy of ranolazine in Hypertrophic Cardiomypathy patients with chest pain or dyspnea despite treatment with standard medical therapy. Ranolazine for the Treatment of Chest Pain in HCM Patients
Interventional Changes in serum markers of collagen turnover Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy
Observational  To devise a safe moderate intensity exercise training program in patients with HCM, and 2) to determine whether exercise training improves ability to perform activities and tasks, heart size and function, and quality of life in patients with HCM. Exercise Study Including Patients With Hypertrophic Cardiomyopathy
Observational  To learn about the twisting or wringing motion of the heartbeat called torsion which can be seen on ultrasound Assessment of Left Ventricular Torsion by Echocardiography Study
Observational 10 year study to identify and trend care parameters, adverse events in the congenital muscle diseases using the Congenital Muscle Disease International Registry (CMDIR).  Congenital Muscle Disease Study of Patient and Family Reported Medical Information